Microphthalmia‐associated transcription factor in melanoma development and MAP ‐kinase pathway targeted therapy
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چکیده
منابع مشابه
Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy
Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia-associated transcription factor (MITF) is essential for the existence of melanocytes. MITF's relevance for this cell lineage is maintained in melanoma, where it is an important regulator of survival and balances melanoma cell proliferation with terminal differentiation (pigmentation). The MITF gene is amplified in ~20% of m...
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ژورنال
عنوان ژورنال: Pigment Cell & Melanoma Research
سال: 2015
ISSN: 1755-1471,1755-148X
DOI: 10.1111/pcmr.12370